Regulation of β1-integrin-mediated cell adhesion by the CbI adaptor protein
نویسندگان
چکیده
Background: Leukocyte activation results in a rapid increase in adhesion to the extracellular matrix due to the activation of β1 integrin receptors. A role for phosphatidylinositol (PI) 3-kinase in integrin activation has been proposed, as activation of integrins by many receptors can be blocked by PI 3-kinase inhibitors. One receptor that regulates integrins is the CD28 surface antigen; here, we investigated the mechanisms responsible for CD28-mediated integrin activation.
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عنوان ژورنال:
- Current Biology
دوره 8 شماره
صفحات -
تاریخ انتشار 1998